HCID 90014371, compound → HCID 90015148, compound

HRID 930993Notes

Reaction equation

HRID 930993 reaction equation
Cl[C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([N:17]([CH2:22][CH2:23][O:24][CH3:25])[CH2:18][CH2:19][O:20][CH3:21])=[O:16])[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:26][C:27]1[C:36]([O:37][CH3:38])=[CH:35][C:30]2[NH:31][C:32](=[O:34])[S:33][C:29]=2[CH:28]=1>>[CH3:21][O:20][CH2:19][CH2:18][N:17]([CH2:22][CH2:23][O:24][CH3:25])[C:15]([CH:13]1[CH2:12][CH2:11][C:10]2[C:3]3[C:2]([NH:26][C:27]4[C:36]([O:37][CH3:38])=[CH:35][C:30]5[NH:31][C:32](=[O:34])[S:33][C:29]=5[CH:28]=4)=[N:7][CH:6]=[N:5][C:4]=3[S:8][C:9]=2[CH2:14]1)=[O:16]

Participants

3

Reactant 2

HCID 90014371HCID 90014371, compoundHCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-one

Product 1

HCID 90015148HCID 90015148, compound

Procedure

150 mg (391 μmol) (RS)-4-chloro-N,N-bis(2-methoxyethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide (prepared according to intermediate example 93a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 27.1 mg (12%) of the title compound.

Workup

  1. customto give
  2. custompurification 27.1 mg (12%) of the title compound

Sources & evidence

ORD record
ord-b23d3e994c98471ea433b2b5c63601a7
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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