HCID 72207396, compound → HCID 90014798, compound

HRID 930995Notes

Reaction equation

HRID 930995 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12]3[C:13]4[C:20]5[CH2:21][CH2:22][CH:23]([C:25]([OH:27])=O)[CH2:24][C:19]=5[S:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:10][C:4]=2[S:3]1.C(O)(=O)C(O)=O.[O:34]1[C:37]2([CH2:40][NH:39][CH2:38]2)[CH2:36][CH2:35]1>>[O:34]1[C:37]2([CH2:40][N:39]([C:25]([CH:23]3[CH2:22][CH2:21][C:20]4[C:13]5[C:12]([NH:11][C:9]6[CH:8]=[CH:7][C:5]7[NH:6][C:2](=[O:1])[S:3][C:4]=7[CH:10]=6)=[N:17][CH:16]=[N:15][C:14]=5[S:18][C:19]=4[CH2:24]3)=[O:27])[CH2:38]2)[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 72207396HCID 72207396, compoundHCID 90014843HCID 90014843, compound

Product 1

HCID 90014798HCID 90014798, compound

Procedure

50 mg (125 μmol) (RS)-4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to example 2) were transformed in analogy to example 3 using 1-oxa-6-azaspiro[3.3]heptane ethanedioate (1:1) to give after working up and purification 31.7 mg (50%) of the title compound.

Workup

  1. customto give
  2. custompurification 31.7 mg (50%) of the title compound

Sources & evidence

ORD record
ord-ddf1fc2d652e4f058fe384960b0874f2
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

Loading…