Methyl iodide → HCID 74221696, compound

Participants

Reaction Steps

To a solution of 8-(1,3-oxazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide (55 mg) and iodomethane (18 μL) in DMF (2 mL) was added 60% sodium hydride (8.7 mg), and the mixture was stirred at room temperature for 1 hr. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane), and the obtained solid was recrystallized from ethyl acetate/hexane to give the title compound (47 mg).

Provenance & Evidence