Hydrochloric Acid → HCID 118378993, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-8-bromo-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide (286 mg) in THF (10 mL) was added dropwise 1M methylmagnesium bromide THF solution (2.1 mL) under ice-cooling. The reaction mixture was stirred at 0° C. for 20 min, 1N hydrochloric acid was added thereto, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a crude product.

Provenance & Evidence