HuagongsheHuagongshe Chemistry Print Report · For research reference only
benzyl 1-(4-fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylate → 1-(4-Fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | benzyl 1-(4-fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylate | HCID 89853924 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylic acid | HCID 89853336 | 93.1% |
Reaction Steps
A solution of benzyl 1-(4-fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylate (115 mg, 0.442 mmol) in methanol (20 mL) was hydrogenated using the H-Cube (full H2, room temperature). The solvent was removed under reduced pressure to afford the title compound as a solid (70 mg). MS (AP+) (M+H) 171.4; LCMS retention time 1.06 minutes (Method M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296745B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-883e9af6f66948b195b95b152208356e |
| Source note | uspto-grants-2016_03 |