Hydrochloric Acid → HCID 89854214, compound

Participants

Reaction Steps

1-(Pyrimidin-5-yl)cyclopropanecarbonitrile (28 mg, 0.19 mmol) was suspended into ethanol (2 mL) previously saturated with gaseous hydrogen chloride. Hydrogen chloride was bubbled for an additional 30 seconds through the mixture and the resulting mixture was stirred for 18 h at room temperature. The solvent was removed under a flow of nitrogen to afford the title compound as a white solid (43 mg) which was used without further purification. 1H NMR (500 MHz, CD3OD) δ 1.45 (t, 3H), 1.70-1.76 (m, 2H), 1.98-2.07 (m, 15H), 4.43 (q, 2H), 8.96 (s, 2H), 9.24 (s, 1H).

Provenance & Evidence