HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → ((R)-1-(5,6-Diaminopyridin-2-yl)piperidin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Reactant | (R)-(1-(5,6-Diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone dihydrochloride | HCID 89854051 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | ((R)-1-(5,6-Diaminopyridin-2-yl)piperidin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone dihydrochloride | HCID 117966358 | — |
Reaction Steps
The title compound was prepared by a method analogous to the one used for Intermediate 1, but using (S)-pyrrolidin-3-ol instead of pyrrolidine for Step 1 and a hydrogen chloride solution in methanol (1.25 M) for Step 2. MS (ES+) (M+H) 306.1; LCMS retention time: 0.26 minutes (Method M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296745B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c4f3bf3b5e9140b7b3be2d11f717301e |
| Source note | uspto-grants-2016_03 |