3-Morpholinone → 1-(3-Oxomorpholin-4-yl)cyclopropane-1-carboxylic acid

HRID 931102Notes

Reaction equation

HRID 931102 reaction equation
FC1C=NN([C:7]2([C:10]([OH:12])=[O:11])[CH2:9][CH2:8]2)C=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][C:14]1=[O:19]>>[O:19]=[C:14]1[N:13]([C:7]2([C:10]([OH:12])=[O:11])[CH2:9][CH2:8]2)[CH2:18][CH2:17][O:16][CH2:15]1

Participants

3

Reactant 2

HCID 669533-MorpholinoneHCID 898533361-(4-Fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylic acid

Product 1

HCID 898538621-(3-Oxomorpholin-4-yl)cyclopropane-1-carboxylic acid

Procedure

The title compound was prepared by a method analogous to the one used for Intermediate 4, but using morpholin-3-one in Step 1. MS (ES+) (M+H) 186.3; LCMS retention time: 0.59 minutes (Method M).

Sources & evidence

ORD record
ord-d88f2b04414d44a4bedb65340edb353f
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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