HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid → (R)-(4-(5,6-Diaminopyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid | HCID 6559076 | — |
| Reactant | (R)-(1-(5,6-Diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone dihydrochloride | HCID 89854051 | — |
| Product | (R)-(4-(5,6-Diaminopyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone dihydrochloride | HCID 117966380 | — |
Reaction Steps
The title compound was prepared by a method analogous to the one used for Intermediate 1, but using (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid for Step 1. 1H NMR (400 MHz, CD3OD) δ 1.81-2.03 (m, 4H) 3.37-3.51 (m, 3H) 3.60-3.73 (m, 3H) 3.75-3.85 (m, 2H) 3.90-3.97 (m, 2H) 4.49 (dd, 1H) 6.40 (d, 1H) 7.73 (d, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296745B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-25dbc536175d4666ae77a9ceddc09b5e |
| Source note | uspto-grants-2016_03 |