2-(4-Methoxypyrazol-1-yl)acetonitrile → Ethyl 1-(4-methoxy-1H-pyrazol-1-yl)cyclopropanecarbimidate

HRID 931149Notes

Reaction equation

HRID 931149 reaction equation
Cl[C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10](=[NH:14])[O:11][CH2:12][CH3:13])[CH2:9][CH2:8]2)[CH:6]=1.[CH3:15][O:16]C1C=NN(CC#N)C=1>>[CH3:15][O:16][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10](=[NH:14])[O:11][CH2:12][CH3:13])[CH2:9][CH2:8]2)[CH:6]=1

Participants

3

Reactant 2

HCID 898543632-(4-Methoxypyrazol-1-yl)acetonitrileHCID 117966385ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

Product 1

HCID 117966276Ethyl 1-(4-methoxy-1H-pyrazol-1-yl)cyclopropanecarbimidate

Procedure

The title compound was prepared by a method analogous to the one used for Intermediate 56, but using 2-(4-methoxy-1H-pyrazol-1-yl)acetonitrile as the starting material. 1H NMR (500 MHz, CDCl3) δ 1.37 (t, 3H), 1.63-1.72 (m, 4H), 3.76 (s, 3H), 4.16 (q, 2H), 7.17 (s, 1H), 7.35 (s, 1H).

Sources & evidence

ORD record
ord-19bf543ae01d406194b4773585d10c1a
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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