Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate | HCID 643516 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (-)-Nipecotic acid | HCID 1796510 | — |
Reaction Steps
To a solution of (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (12.25 mmol) in dichloromethane (84 mL) was added a solution of hydrogen chloride in 1,4-dioxane (28 mL, 4M). The reaction mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidine-3-carboxylic acid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09296745B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-5fd8378b65ea47ea994e7fedc7b081c9 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
