HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931197Generated: November 1, 2026
Dimethylformamide → (R)-1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylic acid
https://huagongshe.com/reaction/931197
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (-)-Nipecotic acid | HCID 1796510 | — |
| Reactant | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
| Product | (R)-1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylic acid | HCID 89853836 | — |
Reaction Steps
A solution of 6-chloro-3-nitropyridin-2-amine in N,N-dimethylformamide (70 mL, 12.25 mmol, 0.175M) was added to (R)-piperidine-3-carboxylic acid (12.25 mmol) followed by diisopropylethylamine (4.55 mL, 24.5 mmol). The reaction mixture was stirred at 80° C. for 16 h. The solvent was removed under reduced pressure to afford (R)-1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylic acid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296745B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-2f00c391f76448ad97a74f318022d5e0 |
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| Source note | uspto-grants-2016_03 |
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