Water → (R)-1-(5,6-diaminopyridin-2-yl)piperidine-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylic acid in N,N-dimethylformamide (91 mL) was added water (9.8 mL), ammonium formate (3.85 g, 61.25 mmol), and active zinc dust (2.1 g, 30.6 mmol) under a nitrogen atmosphere. The reaction mixture was stirred at 45° C. for 16 h. The mixture was filtered and concentrated under reduced pressure to afford (R)-1-(5,6-diaminopyridin-2-yl)piperidine-3-carboxylic acid which was used without further purification.

Provenance & Evidence