Tetrabutylammonium Fluoride → HCID 178521007, compound

Participants

Reaction Steps

Tetrabutylammonium fluoride (1M in tetrahydrofuran, 0.6 mL, 0.6 mmol) was added to a solution of (R)-(1-(2-(6-(1-((tert-butyldimethylsilyl)oxy)cyclopropyl)pyridin-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone (89.7 mg, 0.2 mmol) in tetrahydrofuran (0.5 mL). The reaction mixture was stirred at room temperature for 40 min. The mixture was partitioned between water and ethyl acetate (3×). The combined organics were dried over sodium sulfate and concentrated under reduced pressure. The residue was purified via HPLC to afford the title compound. MS (ESI+) (M+H) 433.1; HPLC retention time 2.1091 min (Method B).

Provenance & Evidence