6-Cyclopropylpicolinaldehyde → HCID 178521046, compound

HRID 931235Notes

Reaction equation

HRID 931235 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][C@@H:10]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:15])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[N+:21]([O-])=O.[CH:24]1([C:27]2[N:32]=[C:31]([CH:33]=O)[CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[N:32]=[C:31]([C:33]3[NH:1][C:2]4=[N:7][C:6]([N:8]5[CH2:13][CH2:12][O:11][C@@H:10]([C:14]([N:16]6[CH2:20][CH2:19][CH2:18][CH2:17]6)=[O:15])[CH2:9]5)=[CH:5][CH:4]=[C:3]4[N:21]=3)[CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 193617216-CyclopropylpicolinaldehydeHCID 117966329(R)-(4-(6-amino-5-nitropyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone

Product 1

HCID 178521046HCID 178521046, compound

Procedure

The title compound was prepared by a method analogous to the one used for Example 112, but using Intermediate 31 and 6-cyclopropylpicolinaldehyde. MS (ES+) (M+H) 418.9; LCMS retention time 2.411 (Method G).

Sources & evidence

ORD record
ord-0b415f85a8384933b0e219e0ffe37146
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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