Ethyl 6-cyclopropylpyrazine-2-carbimidate → HCID 178521047, compound

HRID 931236Notes

Reaction equation

HRID 931236 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([C:10](=[NH:14])OCC)[CH:7]=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([N:23]2[CH2:28][CH2:27][O:26][C@@H:25]([C:29]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:30])[CH2:24]2)=[N:20][C:21]=1N.Cl.Cl.NC1C=CC(N2CCO[C@@H](C(N3CCCC3)=O)C2)=NC=1N>>[CH:1]1([C:4]2[N:9]=[C:8]([C:10]3[NH:14][C:21]4=[N:20][C:19]([N:23]5[CH2:28][CH2:27][O:26][C@@H:25]([C:29]([N:31]6[CH2:32][CH2:33][CH2:34][CH2:35]6)=[O:30])[CH2:24]5)=[CH:18][CH:17]=[C:16]4[N:15]=3)[CH:7]=[N:6][CH:5]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 89853280Ethyl 6-cyclopropylpyrazine-2-carbimidate2×HCID 117966380(R)-(4-(5,6-Diaminopyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone dihydrochlorideHCID 117966381(R)-(4-(5,6-diaminopyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone

Product 1

HCID 178521047HCID 178521047, compound

Procedure

The title compound was prepared by a method analogous to Example 105 using ethyl 6-cyclopropylpyrazine-2-carbimidate (Intermediate 30) and (R)-(4-(5,6-diaminopyridin-2-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone (Intermediate 29). MS (ESI+) (M+H) 420.2; HPLC retention time 2.432 min (Method A).

Sources & evidence

ORD record
ord-aa9093093ffc456b9938a39a5a549c94
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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