(R)-ethyl 1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylate → (R)-ethyl 1-(5,6-diaminopyridin-2-yl)piperidine-3-carboxylate

Participants

Reaction Steps

To a solution of (R)-ethyl 1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylate (300 mg, 1.019 mmol) in ethanol (15 mL) was added a suspension of 10% palladium-on-carbon (200 mg) in ethanol under nitrogen atmosphere. The mixture was hydrogenated using a hydrogen balloon for 2 h at room temperature then was filtered through a pad of Celite. The filtrate was concentrated to afford (R)-ethyl 1-(5,6-diaminopyridin-2-yl)piperidine-3-carboxylate (250 mg) which was used without further purification.

Provenance & Evidence