HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931310Generated: November 3, 2026
2,2,2-Trifluoroethanol → HCID 178521025, compound
https://huagongshe.com/reaction/931310
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Methyl 2,2,2-trichloroacetimidate | HCID 100479 | — |
| Reactant | (R)-(1-(5,6-Diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone dihydrochloride | HCID 89854051 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 178521025 | HCID 178521025 | — |
Reaction Steps
Formic acid (2.8 mL) and trifluoroethanol (61 mL) were added to (R)-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone dihydrochloride. Methyl 2,2,2-trichloroacetimidate (1.65 mL) was added and the reaction mixture was stirred at 60° C. for 3 h. The mixture was used for the next step without further workup or purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09296745B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-fd74be0c953c43b29ed11319b1581b77 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
