(R)-ethyl 1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylate → (R)-ethyl 1-(5,6-diaminopyridin-2-yl)piperidine-3-carboxylate

Participants

Reaction Steps

To a solution of (R)-ethyl 1-(6-amino-5-nitropyridin-2-yl)piperidine-3-carboxylate (1.0 g, 3.39 mmol) in ethanol (30 mL) was added a suspension of 10% palladium-on-carbon (500 mg) in ethanol at room temperature. The mixture was hydrogenated using a balloon filled with hydrogen gas for 4 h. The mixture was filtered through a pad of Celite and the filtrate was used for the next step without further purification.

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