(R)-(1-(6-amino-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone → (R)-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone

Participants

Reaction Steps

To a solution of (R)-(1-(6-amino-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone (0.11 g, 0.34 mmol) in ethanol (15 mL) was added 10% palladium-on-carbon (210 mg). The resulting suspension was hydrogenated using a balloon filled with hydrogen gas for 3 h at room temperature. The mixture was filtered through a pad of Celite and the filtrate was used for the next step without further purification.

Provenance & Evidence