Sulfur → HCID 178521021, compound

Participants

Reaction Conditions

Reaction Steps

1-(1H-Imidazol-1-yl)cyclopropanecarbaldehyde (60 mg, 0.44 mmol), sulfur (10 mg), and acetic acid (0.5 mL) were added to the filtrate containing (R)-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone, prepared in the previous step, The reaction mixture was heated at 80° C. for 24 h. The solvent was removed under reduced pressure and the resulting crude material was purified via preparative TLC (10% methanol in dichloromethane) to afford the title compound. MS (ES+APCI) 406.1; LCMS retention time 4.739 min (Method R1).

Provenance & Evidence