(R)-(1-(6-amino-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone → (R)-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone

Participants

Reaction Steps

To a solution of (R)-(1-(6-amino-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone (0.500 g, 1.56 mmol) in ethanol (25 mL) was added palladium on carbon 10% (500 mg) suspended in ethanol. The reaction mixture was hydrogenated using a balloon filled with hydrogen gas for 3 h at room temperature. The reaction mixture was filtered through Celite and the filtrate was used for the next step without further purification.

Provenance & Evidence