Methanol → HCID 90050656, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-bromo-3H-spiro[1-benzofuran-2,3′-pyrrolo[2,3-b]pyridine]-2′,3(1′H)-dione (300 mg, 0.91 mmol), sodium acetate (149 mg, 1.81 mmol) and dichloro 1,1′-bis(diphenylphosphino)ferrocene palladium(II) dichloromethane adduct (18 mg, 0.023 mmol) in MeOH (5 mL) is pressurized to 120 psi with carbon monoxide and then heated at 80° C. for 12 h with stirring. The reaction mixture is diluted with water (20 mL), and the precipitate collected by filtration, washed with water, and dried under nitrogen atmosphere to give the title compound.

Provenance & Evidence