Methyl 4-(4-{[(3,5-Dimethylphenyl)sulfonyl]methyl}-5-methyl-1,3-oxazol-2-yl)benzoate → 4-(4-{[(3,5-Dimethylphenyl)sulfonyl]methyl}-5-methyl-1,3-oxazol-2-yl)benzoic Acid

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Reaction Steps

Reaction of benzoate 25 (346 mg, 0.87 mmol) and 6 M HCl (10 mL) gave acid 26 (335 mg, 100%) as a white solid: mp (H2O) 265-268° C.; 1H NMR δ 13.16 (br s, 1H, CO2H), 8.05 (dd, J=8.5, 1.8 Hz, 2H, H-2, H-6), 7.93 (ddd, J=8.5, 1.8 Hz, 2H, H-3, H-5), 7.41 (br s, 2H, H-2′, H-6′), 7.37 (br s, 1H, H-4′), 4.62 (s, 2H, CH2SO2), 2.32 (s, 6H, 2×CH3), 2.19 (s, 3H, CH3); MS m/z 386.5 MH+, 100%). Anal. calcd for C20H19NO5S: C, 62.32; H, 4.97; N, 3.63. Found: C, 62.59; H, 4.84; N, 3.58%.

Provenance & Evidence