Sodium Hydroxide → HCID 68278368, compound

Participants

Reaction Steps

Reaction of benzoate 28 (320 mg, 0.71 mmol) and 2 M NaOH (10 mL) in dioxane (10 mL) gave acid 29 (216 mg, 70%) as a white solid: mp (DCM)>310° C.; 1H NMR δ 13.15 (br s, 1H, CO2H), 7.93 (br d, J=8.3 Hz, 2H, H-2, H-6), 7.84 (ddd, J=8.6, 2.3, 1.7 Hz, 2H, H-2′, H-6′), 7.68-7.73 (m, 4H, H-3, H-5, H-3′, H-5′), 4.70 (s, 2H, CH2SO2), 2.19 (s, 3H, CH3); MS m/z 437.0 (MH+, 100%), 439.0 (MH+, 100%). Anal. calcd for C18H14BrNO5S.½CH2Cl2: C, 47.08; H, 3.12; N, 2.89. Found: C, 47.09; H, 2.80; N, 2.99%.

Provenance & Evidence