Sodium Hydroxide → HCID 68278296, compound

Participants

Reaction Steps

Reaction of benzoate 40 (355 mg, 0.82 mmol) and 2 M NaOH (10 mL) in dioxane (10 mL) gave acid 41 (329 mg, 96%) as a white solid: mp (H2O) 221-223° C.; 1H NMR δ 13.16 (br s, 1H, CO2H), 8.05 (d, J=8.4 Hz, 2H, H-2, H-6), 7.94 (d, J=8.4 Hz, 2H, H-3, H-5), 7.33 (dd, J=8.5, 2.0 Hz, 1H, H-6′), 7.26 (d, J=2.0 Hz, 1H, H-2′), 7.14 (d, J=8.5 Hz, 1H, H-5′), 4.63 (s, 2H, CH2SO2), 3.84 (s, 3H, OCH3), 3.76 (s, 3H, OCH3), 2.16 (s, 3H, CH3); MS m/z 418.6 (MH+, 100%). Anal. calcd for C20H19NO7S.½H2O: C, 56.33; H, 4.73; N, 3.29. Found: C, 56.02; H, 4.59; N, 3.36%.

Provenance & Evidence