Sodium Hydroxide → HCID 68278282, compound

Participants

Reaction Steps

Reaction of benzoate 43 (131 mg, 0.34 mmol) and 1 M NaOH (10 mL) in dioxane (10 mL) gave acid 44 (109 mg, 83%) as a white solid: mp (H2O) 235-238° C.; 1H NMR δ 13.15 (br s, 1H, CO2H), 8.06 (br d, J=8.5 Hz, 2H, H-2, H-6), 7.90 (br d, J=8.5 Hz, 2H, H-3, H-5), 7.57 (d, J=8.1 Hz, 1H, H-6′), 7.28 (br s, 1H, H-3′), 7.17 (br d, J=8.1 Hz, 1H, H-5′), 4.61 (s, 2H, CH2SO2), 2.56 (s, 3H, CH3), 2.33 (s, 3H, CH3), 2.16 (s, 3H, CH3); MS m/z 386.5 (MH+, 100%). Anal. calcd for C20H19NO5S.¾H2O: C, 62.69; H, 5.50; N, 3.32. Found: C, 62.52; H, 5.27; N, 3.48%.

Provenance & Evidence