Sodium Hydroxide → HCID 68278589, compound

Participants

Reaction Steps

Reaction of benzoate 46 (491 mg, 1.26 mmol) and 1 M NaOH (10 mL) in dioxane (10 mL) gave acid 47 (354 mg, 75%) as a white solid: mp (H2O) 269-272° C.; 1H NMR δ 13.20 (br s, 1H, CO2H), 8.05 (d, J=8.5 Hz, 2H, H-2, H-6), 7.91 (d, J=8.5 Hz, 2H, H-3, H-5), 7.84-7.89 (m, 2H, H-2′, H-6′), 7.47 (br t, J=8.8 Hz, 2H, H-3′, H-5′), 4.74 (s, 2H, CH2SO2), 2.06 (s, 3H, CH3); MS m/z 376.5 (MH+, 100%). Anal. calcd for C18H14FNO5S.¼H2O: C, 56.91; H, 3.85; N, 3.69. Found: C, 57.15; H, 3.63; N, 3.59%.

Provenance & Evidence