HCID 68278008, compound → HCID 44121587, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(5-methyl-4-(p-tolyloxymethyl)oxazol-2-yl)benzoate (1.0 g, 2.97 mmol, 1.00 equiv) in 6N hydrochloric acid (30 mL) was stirred overnight at 90° C. The reaction mixture was diluted with 50 mL of water then extracted with 3×150 mL of ethyl acetate. The combined organic layers was washed with 3×50 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum to give 0.24 g (25%) of 4-(5-methyl-4-(p-tolyloxymethyl)oxazol-2-yl)benzoic acid as a gray solid. LC-MS: (ES, m/z): 324 [M+H]+, 302, 265, 120. H-NMR: 1HNMR (400 MHz, CDCl3, ppm) δ 8.15-8.13 (d, 2H), 8.06-8.04 (d, 2H), 6.94-6.91 (m, 4H), 3.79 (s, 2H), 2.44 (s, 3H,), 2.26 (s, 3H).

Provenance & Evidence