4-Methylbenzophenone → 4-(Bromomethyl)benzophenone

Participants

Reaction Steps

4-methylbenzophenone (10.0 g; 51.0 mmol) was dissolved in benzene (60 mL) and the solution was warmed to reflux. Solution of bromine (8.39 g; 52.5 mmol) in benzene (15 mL) was added to the reaction mixture over 10 h. The reaction was refluxed for a further 6 h until a light orange solution in obtained and all bromine is consumed. The benzene solvent was evaporated and crude product was obtained as an off-white solid. Recrystallisation from methanol (130 mL) provided 4-(bromomethyl)benzophenone (14.5 g; 69% yield) as a white crystalline solid.

Provenance & Evidence