5-Amino-2-hydroxytoluene → 2,7-Dimethylquinolin-6-ol

HRID 931706Notes

Reaction equation

HRID 931706 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][C:3]=1[O:13]C.N[C:16]1C=CC(O)=C(C)C=1>>[CH3:12][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([CH3:16])=[C:3]([OH:13])[CH:4]=2)[N:9]=1

Participants

3

Reactant 2

HCID 760815-Amino-2-hydroxytolueneHCID 666317827-Chloro-6-methoxy-2-methylquinoline

Product 1

HCID 666314242,7-Dimethylquinolin-6-ol

Procedure

Compound 2B was prepared following the procedure used to prepare compound 1B of Example 1, except that 4-amino-2-methylphenol (2A) was used instead of compound 1A. LCMS-ESI+ (m/z): 174.2 (M+H)+.

Sources & evidence

ORD record
ord-661cb4a353af4612916859111682af6c
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

Loading…