5-Bromo-7-chloro-2-methylquinolin-6-ol → 5-Bromo-2,7-dimethylquinolin-6-ol

HRID 931707Notes

Reaction equation

HRID 931707 reaction equation
[Br:1][C:2]1[C:11]([OH:12])=[C:10](Cl)[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:14])=[N:7]2.[CH3:15]C1C=CC2C(=CC(C)=C(O)C=2)N=1>>[Br:1][C:2]1[C:11]([OH:12])=[C:10]([CH3:15])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:14])=[N:7]2

Participants

3

Reactant 2

HCID 666313995-Bromo-7-chloro-2-methylquinolin-6-olHCID 666314242,7-Dimethylquinolin-6-ol

Product 1

HCID 666314165-Bromo-2,7-dimethylquinolin-6-ol

Procedure

Compound 2C was prepared following the procedure used to prepare compound 1D of Example 1, except that 2,7-dimethylquinolin-6-ol (2B) was used instead of compound 1C. LCMS-ESI+ (m/z): 252.2, 254.2 (M+H)+.

Sources & evidence

ORD record
ord-627ad1fbc556470fa3d5d3e6e4e12fdd
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

Loading…