5-(4-Chlorophenyl)-7-methylquinolin-6-ol → 5-(4-Chlorophenyl)-7-methylquinolin-6-yl trifluoromethanesulfonate

HRID 931718Notes

Reaction equation

HRID 931718 reaction equation
[F:1][C:2]([F:27])([F:26])[S:3]([O:6][C:7]1[C:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[C:9]2[C:14](=[CH:15][C:16]=1Cl)[N:13]=[C:12](C)[CH:11]=[CH:10]2)(=[O:5])=[O:4].Cl[C:29]1C=CC(C2C(O)=C(C)C=C3C=2C=CC=N3)=CC=1>>[F:27][C:2]([F:1])([F:26])[S:3]([O:6][C:7]1[C:8]([C:19]2[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=2)=[C:9]2[C:14](=[CH:15][C:16]=1[CH3:29])[N:13]=[CH:12][CH:11]=[CH:10]2)(=[O:4])=[O:5]

Participants

3

Reactant 2

HCID 666315645-(4-Chlorophenyl)-7-methylquinolin-6-olHCID 866919727-Chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl trifluoromethanesulfonate

Product 1

HCID 866919755-(4-Chlorophenyl)-7-methylquinolin-6-yl trifluoromethanesulfonate

Procedure

Compound 3F was prepared following the procedure used to prepare compound 1F of Example 1, except that 5-(4-chloro-phenyl)-7-methylquinolin-6-ol (3E) was used instead of compound 1E. LCMS-ESI+ (m/z): 402.0, 404.0 (M+H)+.

Sources & evidence

ORD record
ord-1b2cbc7ec4ea4d32b38746c434e00d43
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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