7-Chloro-5-(4-chlorophenyl)-2-methyl-6-vinylquinoline → 5-(4-Chlorophenyl)-7-methyl-6-vinylquinoline

HRID 931719Notes

Reaction equation

HRID 931719 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](C)=[N:9]2)=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH:20]=[CH2:21].F[C:23](F)(F)S(OC1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1C)N=CC=C2)(=O)=O>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:4]2[C:3]([CH:20]=[CH2:21])=[C:2]([CH3:23])[CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 666306227-Chloro-5-(4-chlorophenyl)-2-methyl-6-vinylquinolineHCID 866919755-(4-Chlorophenyl)-7-methylquinolin-6-yl trifluoromethanesulfonate

Product 1

HCID 666310465-(4-Chlorophenyl)-7-methyl-6-vinylquinoline

Procedure

Compound 3G was prepared following the procedure used to prepare compound 1G of Example 1, except that 5-(4-chlorophenyl)-7-methylquinolin-6-yl trifluoromethanesulfonate (3F) was used instead of 1F. LCMS-ESI+ (m/z): 280.2, 282.2 (M+H)+.

Sources & evidence

ORD record
ord-b617ed678ac54597b22c8e5872030b01
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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