(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethanol → (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)ethanol

HRID 931722Notes

Reaction equation

HRID 931722 reaction equation
C(O[C@@H](C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)CO)(C)(C)C.C([O:34][CH2:35][C@@H:36]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])[C:37]1[C:38]([C:48]2[CH:53]=[CH:52][C:51]([Cl:54])=[CH:50][CH:49]=2)=[C:39]2[C:44](=[CH:45][C:46]=1[CH3:47])[N:43]=[CH:42][CH:41]=[CH:40]2)(=O)C(C)(C)C>>[C:56]([O:55][C@@H:36]([C:37]1[C:38]([C:48]2[CH:49]=[CH:50][C:51]([Cl:54])=[CH:52][CH:53]=2)=[C:39]2[C:44](=[CH:45][C:46]=1[CH3:47])[N:43]=[CH:42][CH:41]=[CH:40]2)[CH2:35][OH:34])([CH3:59])([CH3:57])[CH3:58]

Participants

3

Reactant 2

HCID 66631657(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethanolHCID 66631713(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)ethyl pivalate

Product 1

HCID 66631592(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)ethanol

Procedure

Compound 3K was prepared following the procedure used to prepare compound 1K of example 1, except that (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)ethyl pivalate (3J) was used instead of compound 1J. LCMS-ESI+ (m/z): 370.2, 372.2 (M+H)+.

Sources & evidence

ORD record
ord-c0daf7d462f2456aa8f371f895425fae
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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