(S)-2-tert-butoxy-2-(8-(4-chlorophenyl)-6-methylquinolin-7-yl)ethyl pivalate → (S)-2-tert-butoxy-2-(8-(4-chlorophenyl)-6-methylquinolin-7-yl)ethanol

HRID 931727Notes

Reaction equation

HRID 931727 reaction equation
C(O[C@@H](C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)CO)(C)(C)C.C([O:34][CH2:35][C@@H:36]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])[C:37]1[C:46]([C:47]2[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=2)=[C:45]2[C:40]([CH:41]=[CH:42][CH:43]=[N:44]2)=[CH:39][C:38]=1[CH3:54])(=O)C(C)(C)C>>[C:56]([O:55][C@@H:36]([C:37]1[C:46]([C:47]2[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=2)=[C:45]2[C:40]([CH:41]=[CH:42][CH:43]=[N:44]2)=[CH:39][C:38]=1[CH3:54])[CH2:35][OH:34])([CH3:59])([CH3:58])[CH3:57]

Participants

3

Reactant 2

HCID 66631047(S)-2-tert-butoxy-2-(8-(4-chlorophenyl)-6-methylquinolin-7-yl)ethyl pivalateHCID 66631657(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethanol

Product 1

HCID 66631441(S)-2-tert-butoxy-2-(8-(4-chlorophenyl)-6-methylquinolin-7-yl)ethanol

Procedure

Compound 4I was prepared following the procedure used to prepare compound 1K of Example 1, except that (S)-2-tert-butoxy-2-(8-(4-chlorophenyl)-6-methylquinolin-7-yl)ethyl pivalate (4H) was used instead of compound 1J. LCMS-ESI+ (m/z): 370.2, 372.1 (M+H)+.

Sources & evidence

ORD record
ord-f81f68c63d2b40dc815649dd9b171d68
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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