5-Bromo-2,7-dimethylquinolin-6-ol → 5-Bromo-2,7-dimethylquinolin-6-yl trifluoromethanesulfonate

HRID 931728Notes

Reaction equation

HRID 931728 reaction equation
[F:1][C:2]([F:27])([F:26])[S:3](OC1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)(=[O:5])=[O:4].[Br:28][C:29]1[C:38]([OH:39])=[C:37]([CH3:40])[CH:36]=[C:35]2[C:30]=1[CH:31]=[CH:32][C:33]([CH3:41])=[N:34]2>>[F:1][C:2]([F:27])([F:26])[S:3]([O:39][C:38]1[C:29]([Br:28])=[C:30]2[C:35](=[CH:36][C:37]=1[CH3:40])[N:34]=[C:33]([CH3:41])[CH:32]=[CH:31]2)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 666314165-Bromo-2,7-dimethylquinolin-6-olHCID 866919727-Chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl trifluoromethanesulfonate

Product 1

HCID 866919775-Bromo-2,7-dimethylquinolin-6-yl trifluoromethanesulfonate

Procedure

Compound 5A was prepared following the procedure used to prepare compound 1F of Example 1, except that 5-bromo-2,7-dimethylquinolin-6-ol (2C) was used instead of compound 1E. LCMS-ESI+ (m/z): 383.9, 385.9 (M+14)+.

Sources & evidence

ORD record
ord-44d7e9dd4a4b47a8ba8b7b05af929b63
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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