(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)acetic acid → (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetic acid

HRID 931731Notes

Reaction equation

HRID 931731 reaction equation
C([O:5][C@@H](C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)C(O)=O)(C)(C)C.[Br:29][C:30]1[C:39]([C@H:40]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])[CH2:41][OH:42])=[C:38]([CH3:48])[CH:37]=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34]([CH3:49])=[N:35]2>>[Br:29][C:30]1[C:39]([C@H:40]([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[C:41]([OH:5])=[O:42])=[C:38]([CH3:48])[CH:37]=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34]([CH3:49])=[N:35]2

Participants

3

Reactant 2

HCID 56644218(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)acetic acidHCID 66631978(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol

Product 1

HCID 66631643(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetic acid

Procedure

Compound 5G was prepared following the procedure used to prepare compound 1L of Example 1, except that (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol (5F) was used instead of compound 1K. LCMS-ESI+ (m/z): 366.1, 368.1 (M+H)+.

Sources & evidence

ORD record
ord-d5fc2597a99e47fd8ea868aa52db0a37
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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