(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethyl)quinolin-6-yl)ethyl pivalate → (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethyl)quinolin-6-yl)ethanol

HRID 931739Notes

Reaction equation

HRID 931739 reaction equation
C(O[C@@H](C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)CO)(C)(C)C.C([O:34][CH2:35][C@@H:36]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])[C:37]1[C:38]([C:52]2[CH:57]=[CH:56][C:55]([Cl:58])=[CH:54][CH:53]=2)=[C:39]2[C:44](=[CH:45][C:46]=1[CH3:47])[N:43]=[C:42]([C:48]([F:51])([F:50])[F:49])[CH:41]=[CH:40]2)(=O)C(C)(C)C>>[C:60]([O:59][C@@H:36]([C:37]1[C:38]([C:52]2[CH:57]=[CH:56][C:55]([Cl:58])=[CH:54][CH:53]=2)=[C:39]2[C:44](=[CH:45][C:46]=1[CH3:47])[N:43]=[C:42]([C:48]([F:49])([F:51])[F:50])[CH:41]=[CH:40]2)[CH2:35][OH:34])([CH3:63])([CH3:61])[CH3:62]

Participants

3

Reactant 2

HCID 66631326(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethyl)quinolin-6-yl)ethyl pivalateHCID 66631657(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethanol

Product 1

HCID 66631267(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethyl)quinolin-6-yl)ethanol

Procedure

Following the procedure used to prepare compound 1K of Example 1, except that (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethyl)quinolin-6-yl)ethyl pivalate (7H) was used instead of compound 1J. LCMS-ESI+ (m/z): 438.2, 440.2 (M+H)+.

Sources & evidence

ORD record
ord-9c23effdace741f4bad6c4a38f390989
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

Loading…