HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931748Generated: October 31, 2026
Methylamine → (S)-2-(5-bromo-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyethyl pivalate
https://huagongshe.com/reaction/931748
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (S)-2-(2-acetoxy-5-bromo-7-methylquinolin-6-yl)-2-tert-butoxyethyl pivalate | HCID 66631898 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-2-(5-bromo-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyethyl pivalate | HCID 66631083 | 57.3% |
Reaction Steps
To the solution of (S)-2-(2-acetoxy-5-bromo-7-methylquinolin-6-yl)-2-tert-butoxyethyl pivalate (130 mg) in ethanol (7.5 mL) was added aqueous methylamine solution (0.5 mL, 50%). The mixture was heated at 78° C. for 80 min. Concentration and purification gave (S)-2-(5-bromo-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyethyl pivalate (68 mg). LCMS-ESI+ (m/z): 438.2, 440.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296758B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-2fd31e5ecc904a5ea0b2df79d4deaa57 |
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| Source note | uspto-grants-2016_03 |
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