HRID931755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(C)cc2n1

HCID66631480

未命名化合物

结构：Cc1cc2c(ccc(C)[n+]2[O-])c(Br)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID66631609

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2c(ccc(C)[n+]2[O-])c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID66631094

未命名化合物

PROCEDURE

实验过程

Following the procedure used to prepare compound (S)-5-bromo-6-(1-tert-butoxy-2-(pivaloyloxy)ethyl)-2,7-dimethylquinoline 1-oxide of Example 9, except that (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2,7-dimethylquinolin-6-yl)ethyl pivalate was used instead of (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethyl pivalate. LCMS-ESI+ (m/z): 484.3, 486.3 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ee662c8493724d59ad30a1c269c9b5bc
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09296758B2
来源说明: uspto-grants-2016_03

反应 SMILES

Br[C:2]1[C:11]([C@H:12]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])[CH2:13][O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[C:10]([CH3:26])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:28])=[N+:7]2[O-:27].C(OC[C@@H](OC(C)(C)C)C1C([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[CH:52][CH:51]=2)=C2C(=CC=1C)N=C(C)C=C2)(=O)C(C)(C)C>>[C:22]([O:21][C@@H:12]([C:11]1[C:2]([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[CH:52][CH:51]=2)=[C:3]2[C:8](=[CH:9][C:10]=1[CH3:26])[N+:7]([O-:27])=[C:6]([CH3:28])[CH:5]=[CH:4]2)[CH2:13][O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:25])([CH3:24])[CH3:23]