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HRID931773

反应详情

EQUATION

反应方程式

HRID 931773 的结构方程式

REACTANTS

反应物

2
反应SMILES：Cc1cc2nc(CN(C)c3ccccc3)ccc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O
HCID56644638

未命名化合物

反应SMILES：CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(C(=O)N(C)c3ccccc3)ccc2c1-c1ccc(Cl)cc1
HCID68093221

未命名化合物

PRODUCTS

产物

1
反应SMILES：Cc1cc2nc(C(=O)N(C)c3ccccc3)ccc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O
HCID56644857

未命名化合物

PROCEDURE

实验过程

(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(methyl(phenyl)carbamoyl)quinolin-6-yl)acetic acid was prepared following the procedure used to prepare compound (S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino)methyl)quinolin-6-yl)acetic acid of Example 14, except that (S)-ethyl 2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(methyl(phenyl)carbamoyl)quinolin-6-yl)acetate was used instead of (S)-ethyl 2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino)methyl) quinolin-6-yl)acetate. 1H-NMR 300 MHz, (CD3OD) δ 7.80-7.50 (m, 6H), 7.40-7.10 (m, 6H), 5.16 (s, 1H), 3.54 (s, 3H), 2.62 (s, 3H), 0.95 (s, 9H); LCMS-ESI+ (m/z): [M+H]+ calcd for C30H30ClN2O4: 518.0. Found: 517.2, 519.2.