(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino) methyl)quinolin-6-yl)acetic acid → (S)-2-tert-Butoxy-2-(5-cyclohexenyl-2-((dimethylamino)methyl)-7-methylquinolin-6-yl)acetic acid

Participants

Reaction Steps

(S)-2-tert-Butoxy-2-(5-cyclohexenyl-2-((dimethylamino)methyl)-7-methylquinolin-6-yl)acetic acid was prepared following the procedure used to prepare compound (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino) methyl)quinolin-6-yl)acetic acid of Example 14, except that (S)-ethyl 2-tert-butoxy-2-(5-cyclohexenyl-2-((dimethylamino) methyl)-7-methylquinolin-6-yl)acetate was used instead of (S)-ethyl 2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino)methyl)quinolin-6-yl)acetate. 1H-NMR 300 MHz, (CD3OD) 8.40-8.30 (m, 1H), 7.85-7.78 (m, 1H), 7.42 (d, 1H), 6.04, 5.70 (br, br, 1H), 5.80, 5.64 (s, s, 1H), 4.65 (s, 2H), 3.04 (s, 6H), 2.68-2.56 (m, 4H), 2.40-1.80 (m, 6H), 1.30-1.20 (m, 9H); LCMS-ESI+ (m/z): [M-1-11]+ calcd for C25H34N2O3: 411.6. Found: 411.3.

Provenance & Evidence