Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate | HCID 86691982 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 66631939 | HCID 66631939 | — |
Reaction Steps
A mixture of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate (12 mg, prepared as in Example 26) and morpholine (0.2 mL) in DME was heated at 80° C. for 12 hours. Concentration in vacuo gave (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-morpholinoquinolin-6-yl)ethyl pivalate (15 mg). LCMS-ESI+ (m/z): [M+H]+ calcd for C31H40ClN2O4: 539.3. Found: 539.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09296758B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-414e611596bb4f25925c6b0a4a40e763 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
