Cyclopropylacetylene → (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(2-cyclopropylethyl)-7-methylquinolin-6-yl)acetic acid

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(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-2-(2-cyclopropylethyl)-7-methylquinolin-6-yl)acetic acid (39) (5.7 mg) was prepared in a similar manner as compound (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-phenethylquinolin-6-yl)acetic acid of Example 37 except using ethynylcyclopropane instead of ethynylbenzene. 1H-NMR 400 MHz (CD3OD) δ 8.17 (d, J=8.4 Hz, 1 H), 7.91 (s, 1 H), 7.66 (d, J=8.8 Hz, 1 H), 7.6-7.5 (m, 3 H), 7.31 (m, 1 H), 5.18 (s, 1 H), 3.21 (m, 2 H), 2.71 (s, 3 H), 1.72 (m, 2 H), 0.92 (s, 9 H), 0.75 (m, 1 H), 0.41 (m, 2 H), 0.02 (m, 2 H); LCMS-ESI+ (m/z): [M+H]+ calcd for C27H31ClNO3: 452.2. Found: 452.2.

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