HCID 66631939, compound → (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethanol

HRID 931803Notes

Reaction equation

HRID 931803 reaction equation
C(OC[C@@H](OC(C)(C)C)C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1C)N=C(N1CCOCC1)C=C2)(=O)C(C)(C)C.C([O:45][CH2:46][C@@H:47]([O:68][C:69]([CH3:72])([CH3:71])[CH3:70])[C:48]1[C:49]([C:61]2[CH:66]=[CH:65][C:64]([Cl:67])=[CH:63][CH:62]=2)=[C:50]2[C:55](=[CH:56][C:57]=1[CH3:58])[N:54]=[C:53]([NH:59][NH2:60])[CH:52]=[CH:51]2)(=O)C(C)(C)C>>[C:69]([O:68][C@@H:47]([C:48]1[C:49]([C:61]2[CH:66]=[CH:65][C:64]([Cl:67])=[CH:63][CH:62]=2)=[C:50]2[C:55](=[CH:56][C:57]=1[CH3:58])[N:54]=[C:53]([NH:59][NH2:60])[CH:52]=[CH:51]2)[CH2:46][OH:45])([CH3:72])([CH3:70])[CH3:71]

Participants

3

Reactant 2

HCID 66631939HCID 66631939, compoundHCID 66632199(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethyl pivalate

Product 1

HCID 66631456(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethanol

Procedure

(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethanol was prepared in a similar manner as compound ((S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-morpholinoquinolin-6-yl)ethanol of Example 29 except using (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethyl pivalate instead of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-morpholinoquinolin-6-yl)ethyl pivalate. LCMS-ESI+ (m/z): [M+H]+ calcd for C22H27ClN3O2: 400.2. Found: 400.2.

Sources & evidence

ORD record
ord-4908734d747d42ad8ad8ac732d1839c7
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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