3-Pyridinylboronic acid → HCID 66631619, compound

Participants

Reaction Steps

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(pyridin-3-yl)quinolin-6-yl)acetic acid (74) was prepared following the procedure for (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(pyridin-4-yl)quinolin-6-yl)acetic acid of Example 73 except that pyridin-3-ylboronic acid was used instead of pyridin-4-ylboronic acid. 1H-NMR: 400 MHz, (CD3CN) δ: 9.49 (s, 1 H), 8.94 (d, J=8.4 Hz, 1 H), 8.79 (s, 1 H), 7.91 (m, 2H), 7.80 (Abq, J=26.2, 8.8 Hz, 2 H), 7.58 (m, 3 H), 7.34 (m, 1 H), 5.25 (s, 1 H), 2.61 (s, 3H), 0.97 (s, 9 H). LCMS-ESI+ (m/z): [M+H]+ calcd for C27H26ClN2O3: 461.16. found: 461.00.

Provenance & Evidence