1,3-Thiazol-4-ylboronic acid → HCID 66631620, compound

Participants

Reaction Steps

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(thiazol-4-yl)quinolin-6-yl)acetic acid (76) was prepared following the procedure for (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(1H-pyrazol-5-yl)quinolin-6-yl)acetic acid of Example 70 except that thiazol-4-ylboronic acid was used instead of 1H-pyrazol-5-ylboronic acid and the in the final step the reaction was stirred for 1.5 hours. 1H-NMR: 400 MHz, (CD3CN) δ: 9.07 (d, J=2.0 Hz, 1 H), 8.58 (d, J=2.0 Hz, 1 H), 8.17 (d, J=9.2 Hz, 1 H), 8.02 (s, 1 H), 7.93 (d, J=9.2 Hz, 1 H), 7.59 (m, 3 H), 7.35 (d, J=7.6 Hz, 1 H), 5.25 (s, 1H), 2.64 (s, 3 H), 0.98 (s, 9 H).

Provenance & Evidence