4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 56645464, compound

Participants

Reaction Steps

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(1H-pyrazol-4-yl)quinolin-6-yl)acetic acid (77) was prepared following the procedure for (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(1H-pyrazol-5-yl)quinolin-6-yl)acetic acid of Example 70 except that 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole was used instead of 1H-pyrazol-5-ylboronic acid and the in the final step the reaction was stirred for 1 hour. 1H-NMR: 400 MHz, (CD3CN) δ: 8.45 (s, 2 H), 8.08 (s, 1 H), 7.89 (d, J=8.8 Hz, 1 H), 7.73 9 (d, J=8.8 Hz, 1 H), 7.59 (m, 3 H), 7.34 (d, J=7.2 Hz, 1H), 5.22 (s, 1 H), 2.63 (s, 3 H), 0.97 (s, 9 H). LCMS-ESI+ (m/z): [M+H]+ calcd for C25H25ClN3O3: 450.15. found: 450.53.

Provenance & Evidence