2-(Tributylstannyl)pyridine → HCID 66631734, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate (compound of Example 26; 50 mg, 0.08 mmol) in 1,2 dimethoxyethane (1 mL) was added 2-(tributylstannyl)pyridine (0.040 mL, 0.125 mmol) and Pd(PPh3)4 and the reaction mixture was degassed with argon for 5 minutes. The reaction was heated to 110° C. in a microwave reactor for 20 minutes. The crude reaction mixture was absorbed onto silica gel and purified by flash column chromatography (silica gel, ethyl acetate/hexanes) to give a clear oil (45.2 mg). LCMS-ESI+ (m/z): [M+H]+ calcd for C32H36ClN2O3: 531.23. found: 531.68.

Provenance & Evidence